Paige Arnold, Ph.D.

Paige Arnold is a postdoctoral researcher in the laboratory of Dr. Luciano Marraffini at Rockefeller University. She received a B.S. in biology with a concentration in genomics from Duke University and later earned a Ph.D. in cancer biology from the Gerstner Sloan Kettering (GSK) graduate program of Memorial Sloan Kettering Cancer Center. During her thesis research in the laboratory of Dr. Lydia Finley, Paige studied tricarboxylic acid (TCA) cycle behavior in embryonic stem cells and cancer cells. Her research identified an alternative TCA cycle pathway that is engaged by mammalian cells in a cell-state specific manner and showed that TCA cycle rewiring occurs during cell state transitions. For this work, she was a recipient of the 2022 GSK Chairman’s Prize and the 2022 Harold M. Weintraub Graduate Student Award.

Paige is broadly interested in how metabolic rewiring potentiates changes in cell function and survival. In the Marraffini laboratory, Paige is studying both how bacterial viruses (phages) hijack bacterial metabolic pathways to support their dissemination and how bacteria, in turn, exploit phage dependence on host metabolism to defend themselves against infection.