CCB Colloquium: Kresten Lindorff-Larsen, Ph.D.

Speaker: Kresten Lindorff-Larsen, Ph.D., University of Copenhagen

Title: STRUCTURE PREDICTION AND DESIGN OF INTRINSICALLY DISORDERED PROTEINS

Abstract: Intrinsically disordered proteins and regions (collectively IDRs) are pervasive across proteomes in all kingdoms of life, help shape biological function and are involved in numerous diseases. IDRs populate a diverse set of transiently formed structures yet defy commonly held sequence-structure-function relationships . Recent developments in protein structure prediction have led to the ability to predict the three-dimensional structures of folded proteins at the proteome scale and have enabled large-scale studies of structure-function relationships. In contrast, knowledge of the conformational properties of fully disordered proteins and long disordered linkers is scarce, in part because the sequences of disordered proteins are poorly conserved and because only few have been characterized experimentally. In my talk I will describe how we can use molecular simulations with coarse-grained models and machine learning to study the relationship between sequence, conformational properties, and functions of IDRs.